Meaning Meaning 'saintly' or 'holy' , refering specifically to Saint James. Origin of Santiago Spanish , Latin +-100%Zoom level changed to 1 Popular Middle Names Antonio, Gael, Mateo, Sebastian, Andres, Jose, Alejandro, Daniel, Alexander, Elias Pronunciation 🔊 Listen Santiago SAEN-tiy-AA-gow Similar Names Tiago Santino Jeronimo Christopher Thiago Sinjin Kiyoshi Darweshi Ovi Olezka Year by Year Popularity of Santiago