Meaning This is an alternate spelling of "Alexander," which means defender of mankind. It also calls to mind the conqueror Alexander the Great. Origin of Xzander American +-100%Zoom level changed to 1 Popular Middle Names Armani, Leo Pronunciation 🔊 Listen Xzander KSAN-der Similar Names Alekzander Alexandros Alick Alandair Alessandre Alesandro Alistir Alissander Allissandre Alsandare Year by Year Popularity of Xzander