Meaning A popular Italian name, meaning 'saintly' or 'holy'. Origin of Santino Latin , Spanish Popular Middle Names Francis, Alexander, Alonso, Angelo, Anthony, Blas, Charles, Corleone, David, Dominic Pronunciation 🔊 Listen Santino Saan-TIY-now Similar Names Santiago Farran Farren Kiyoshi Darweshi Marco Mario Calum Girolamo Charlemagne Year by Year Popularity of Santino