Meaning A girl's name of French origin, it means "Serpentine." Origin of Ophelie French +-100%Zoom level changed to 1 Popular Middle Names Pronunciation 🔊 Listen Ophelie Similar Names Amice Esmee Eulalie Lacee Laycie Lorraina Marquisha Gay Hilaire Jacquetta / Jacquet Year by Year Popularity of Ophelie