Meaning A boy's name of African origin, it means " leader of the nation." Origin of Melisizwe African +-100%Zoom level changed to 1 Popular Middle Names Pronunciation 🔊 Listen Melisizwe Similar Names Butholezwe Setjhaba Sizwe Cadwalader Cadwaladyr Cyrus Masopha Quoc Iwi Amram Year by Year Popularity of Melisizwe