Meaning A girl's name of English origin, it means "Variant of Kay and Kayla, meaning: keeper of the keys; pure." Origin of Kailene English +-100%Zoom level changed to 1 Popular Middle Names Gloria Pronunciation 🔊 Listen Kailene Similar Names Kaelah Kaelee Kaeleigh Kaelene Kaeley Kaeli Kailin Kailan Kalee Kalynn Year by Year Popularity of Kailene