Meaning A variant of the Hebrew name from the Old Testament Ephraim meaning fruitful. Origin of Efren Hebrew +-100%Zoom level changed to 1 Popular Middle Names Adrian, Chavez, Esteban, Matteo, Ulises Pronunciation 🔊 Listen Efren EF-ren Similar Names Efrem Zachariah Efraim Ibraham Ephram Ephrem Ephron Efrayim Efran Ethyn Year by Year Popularity of Efren