Meaning A girl's name of French origin, it means "Defender of mankind Feminine of Alexander." Origin of Alyssandra +-100%Zoom level changed to 1 Popular Middle Names Ayvianna, Brianna, Christiana, Giselle, Grace, Kathleen, Mia Pronunciation 🔊 Listen Alyssandra Similar Names Sachenka Sachka Alixandra Lisandra Lexandra Alexandrina Alesandese Sandy Alyx Alastriona Year by Year Popularity of Alyssandra