Meaning A girl's name of French origin, it means "Defender of mankind Feminine of Alexander." Origin of Alixandra French +-100%Zoom level changed to 1 Popular Middle Names Marie, Nicole, Breann, Delilah, Elise, Elizabeth, Grace Pronunciation 🔊 Listen Alixandra Similar Names Sachenka Sachka Alyssandra Lisandra Lexandra Alexandrina Alesandese Sandy Alyx Alastriona Year by Year Popularity of Alixandra