Meaning Variant of Dwayne; happy, joyful, full of life. Origin of DeWayne American Popular Middle Names Devon, James, Kurt, Lee, Miles, Nolan Pronunciation 🔊 Listen DeWayne deWAYn Similar Names Duane Dwade Dwayne Chittaranjan Kadyn Kaeden Kaidyn Aamir Radovan Letitia Year by Year Popularity of DeWayne