Meaning From Hebrew origin meaning 'lance, spear'. Cain, the first son of Adam and Eve who killed his brother out of jealousy. Origin of Caine Hebrew +-100%Zoom level changed to 1 Popular Middle Names Elias, Karl, Lee Pronunciation 🔊 Listen Caine CAYN Similar Names Cane Cain Seth Kayne Kain Lance Launce Qayin Aadam Kaine Year by Year Popularity of Caine