Meaning A variant spelling of the name Aisha, meaning 'alive' this was also the name of the Prophet Muhammed's third and supposedly favorite wife. Origin of Aysha Arabic +-100%Zoom level changed to 1 Popular Middle Names Leigh Pronunciation 🔊 Listen Aysha AY-IYSHAA Similar Names Aesha Ayse Aizah Amena Diya Fatimah Yvie Ayshah Afsa Aaeesha Year by Year Popularity of Aysha